Biblio

We propose a novel hybrid imaging system to acquire 4D high-speed hyperspectral (HSHS) videos with high spatial and spectral resolution. The proposed system consists of two branches: one branch performs Nyquist sampling in the temporal dimension while integrating the whole spectrum, resulting in a high-frame-rate panchromatic video; the other branch performs compressive sampling in the spectral dimension with longer exposures, resulting in a low-frame-rate hyperspectral video. Owing to the high light throughput and complementary sampling, these two branches jointly provide reliable measurements for recovering the underlying HSHS video. Moreover, the panchromatic video can be used to learn an over-complete 3D dictionary to represent each band-wise video sparsely, thanks to the inherent structural similarity in the spectral dimension. Based on the joint measurements and the self-adaptive dictionary, we further propose a simultaneous spectral sparse (3S) model to reinforce the structural similarity across different bands and develop an efficient computational reconstruction algorithm to recover the HSHS video. Both simulation and hardware experiments validate the effectiveness of the proposed approach. To the best of our knowledge, this is the first time that hyperspectral videos can be acquired at a frame rate up to 100fps with commodity optical elements and under ordinary indoor illumination.

Genes, proteins and other metabolites present in cellular environment exhibit a virtual network that represents the regulatory relationship among its constituents. This network is called Gene Regulatory Network (GRN). Computational reconstruction of GRN reveals the normal metabolic pathway as well as disease motifs. Availability of microarray gene expression data from normal and diseased tissues makes the job easier for computational biologists. Reconstruction of GRN is based on neural modeling. Here we have used discrete and continuous versions of a meta-heuristic algorithm named Firefly algorithm for structure and parameter learning of GRNs respectively. The discrete version for this problem is proposed by us and it has been applied to explore the discrete search space of GRN structure. To evaluate performance of the algorithm, we have used a widely used synthetic GRN data set. The algorithm shows an accuracy rate above 50% in finding GRN. The accuracy level of the performance of Firefly algorithm in structure and parameter optimization of GRN is promising.