Biblio

Researchers develop bioassays following rigorous experimentation in the lab that involves considerable fiscal and highly-skilled-person-hour investment. Previous work shows that a bioassay implementation can be reverse engineered by using images or video and control signals of the biochip. Hence, techniques must be devised to protect the intellectual property (IP) rights of the bioassay developer. This study is the first step in this direction and it makes the following contributions: (1) it introduces use of a sieve-valve as a security primitive to obfuscate bioassay implementations; (2) it shows how sieve-valves can be used to obscure biochip building blocks such as multiplexers and mixers; (3) it presents design rules and security metrics to design and measure obfuscated biochips. We assess the cost-security trade-offs associated with this solution and demonstrate practical sieve-valve based obfuscation on real-life biochips.

Present security study involving analysis of manipulation of individual droplets of samples and reagents by digital microfluidic biochip has remarked that the biochip design flow is vulnerable to piracy attacks, hardware Trojans attacks, overproduction, Denial-of-Service attacks, and counterfeiting. Attackers can introduce bioprotocol manipulation attacks against biochips used for medical diagnosis, biochemical analysis, and frequent diseases detection in healthcare industry. Among these attacks, hardware Trojans have created a major threatening issue in its security concern with multiple ways to crack the sensitive data or alter original functionality by doing malicious operations in biochips. In this paper, we present a systematic algorithm for the assignment of checkpoints required for error-recovery of available bioprotocols in case of hardware Trojans attacks in performing operations by biochip. Moreover, it can guide the placement and timing of checkpoints so that the result of an attack is reduced, and hence enhance the security concerns of digital microfluidic biochips. Comparative study with traditional checkpoint schemes demonstrate the superiority of the proposed algorithm without overhead of the bioprotocol completion time with higher error detection accuracy.