Biblio

A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we provide the first assessment of the security vulnerabilities of DMFBs. We identify result-manipulation attacks on a DMFB that maliciously alter the assay outcomes. Two practical result-manipulation attacks are shown on a DMFB platform performing enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the attacker tampers with the calibration curve of the assay operation. We then identify denial-of-service attacks, where the attacker can disrupt the assay operation by tampering either with the droplet-routing algorithm or with the actuation sequence. We demonstrate these attacks using a digital microfluidic synthesis simulator. The results show that the attacks are easy to implement and hard to detect. Therefore, this work highlights the need for effective protections against malicious modifications in DMFBs.

IT industry loses tens of billions of dollars annually from security attacks such as tampering and malicious reverse engineering. Code obfuscation techniques counter such attacks by transforming code into patterns that resist the attacks. None of the current code obfuscation techniques satisfy all the obfuscation effectiveness criteria such as resistance to reverse engineering attacks and state space increase. To address this, we introduce new code patterns that we call nontrivial code clones and propose a new obfuscation scheme that combines nontrivial clones with existing obfuscation techniques to satisfy all the effectiveness criteria. The nontrivial code clones need to be constructed manually, thus adding to the development cost. This cost can be limited by cloning only the code fragments that need protection and by reusing the clones across projects. This makes it worthwhile considering the security risks. In this paper, we present our scheme and illustrate it with a toy example.