Biblio
As digital microfluidic biochips (DMFBs) make the transition to the marketplace for commercial exploitation, security and intellectual property (IP) protection are emerging as important design considerations. Recent studies have shown that DMFBs are vulnerable to reverse engineering aimed at stealing biomolecular protocols (IP theft). The IP piracy of proprietary protocols may lead to significant losses for pharmaceutical and biotech companies. The micro-electrode-dot-array (MEDA) is a next-generation DMFB platform that supports real-time sensing of droplets and has the added advantage of important security protections. However, real-time sensing offers opportunities to an attacker to steal the biochemical IP. We show that the daisychaining of microelectrodes and the use of one-time-programmability in MEDA biochips provides effective bitstream scrambling of biochemical protocols. To examine the strength of this solution, we develop a SAT attack that can unscramble the bitstreams through repeated observations of bioassays executed on the MEDA platform. Based on insights gained from the SAT attack, we propose an advanced defense against IP theft. Simulation results using real-life biomolecular protocols confirm that while the SAT attack is effective for simple instances, our advanced defense can thwart it for realistic MEDA biochips and real-life protocols.
Anti-virus software (AVS) tools are used to detect Malware in a system. However, software-based AVS are vulnerable to attacks. A malicious entity can exploit these vulnerabilities to subvert the AVS. Recently, hardware components such as Hardware Performance Counters (HPC) have been used for Malware detection. In this paper, we propose PREEMPT, a zero overhead, high-accuracy and low-latency technique to detect Malware by re-purposing the embedded trace buffer (ETB), a debug hardware component available in most modern processors. The ETB is used for post-silicon validation and debug and allows us to control and monitor the internal activities of a chip, beyond what is provided by the Input/Output pins. PREEMPT combines these hardware-level observations with machine learning-based classifiers to preempt Malware before it can cause damage. There are many benefits of re-using the ETB for Malware detection. It is difficult to hack into hardware compared to software, and hence, PREEMPT is more robust against attacks than AVS. PREEMPT does not incur performance penalties. Finally, PREEMPT has a high True Positive value of 94% and maintains a low False Positive value of 2%.
Researchers develop bioassays following rigorous experimentation in the lab that involves considerable fiscal and highly-skilled-person-hour investment. Previous work shows that a bioassay implementation can be reverse engineered by using images or video and control signals of the biochip. Hence, techniques must be devised to protect the intellectual property (IP) rights of the bioassay developer. This study is the first step in this direction and it makes the following contributions: (1) it introduces use of a sieve-valve as a security primitive to obfuscate bioassay implementations; (2) it shows how sieve-valves can be used to obscure biochip building blocks such as multiplexers and mixers; (3) it presents design rules and security metrics to design and measure obfuscated biochips. We assess the cost-security trade-offs associated with this solution and demonstrate practical sieve-valve based obfuscation on real-life biochips.
A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we provide the first assessment of the security vulnerabilities of DMFBs. We identify result-manipulation attacks on a DMFB that maliciously alter the assay outcomes. Two practical result-manipulation attacks are shown on a DMFB platform performing enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the attacker tampers with the calibration curve of the assay operation. We then identify denial-of-service attacks, where the attacker can disrupt the assay operation by tampering either with the droplet-routing algorithm or with the actuation sequence. We demonstrate these attacks using a digital microfluidic synthesis simulator. The results show that the attacks are easy to implement and hard to detect. Therefore, this work highlights the need for effective protections against malicious modifications in DMFBs.