The goal of this research is to gain a fundamental understanding of the integrated actuation, embedded sensing, reactive control, and distributed control needs of a cyber-physical, synthetic, distributed sensing, soft and modular tissue (sTISSUE). Realizing this cyber-physical, physiological testbed will enable surgically relevant tasks, procedures, and devices to be much more refined ahead of animal testing, which can be dramatically reduced with such high-fidelity simulators.