Current learning algorithms cannot be easily applied in CPS due to their need for continuous and expensive updates, with the current triggered frameworks having fundamental limitations. Such limitations lead to the following questions. How can we incorporate and fully adapt to totally unknown, dynamic, and uncertain environments? How do we co-design the action and the intermittent schemes? How can we provide quantifiable real-time performance, stability and robustness guarantees by design? And how do we solve congestion and guarantee security?