Biblio

State-of-the-art approaches in gait analysis usually rely on one isolated tracking system, generating insufficient data for complex use cases such as sports, rehabilitation, and MedTech. We address the opportunity to comprehensively understand human motion by a novel data model combining several motion-tracking methods. The model aggregates pose estimation by captured videos and EMG and EIT sensor data synchronously to gain insights into muscle activities. Our demonstration with biceps curl and sitting/standing pose generates time-synchronous data and delivers insights into our experiment’s usability, advantages, and challenges.

Document-level relation extraction (RE) aims to extract relations among entities within a document, which is more complex than its sentence-level counterpart, especially in biomedical text mining. Chemical-disease relation (CDR) extraction aims to extract complex semantic relationships between chemicals and diseases entities in documents. In order to identify the relations within and across multiple sentences at the same time, existing methods try to build different document-level heterogeneous graph. However, the entity relation representations captured by these models do not make full use of the document information and disregard the noise introduced in the process of integrating various information. In this paper, we propose a novel model DAM-GAN to document-level biomedical RE, which can extract entity-level and mention-level representations of relation instances with R-GCN and Dual-Attention Multi-Instance Learning (DAM) respectively, and eliminate the noise with Generative Adversarial Network (GAN). Entity-level representations of relation instances model the semantic information of all entity pairs from the perspective of the whole document, while the mention-level representations from the perspective of mention pairs related to these entity pairs in different sentences. Therefore, entity- and mention-level representations can be better integrated to represent relation instances. Experimental results demonstrate that our model achieves superior performance on public document-level biomedical RE dataset BioCreative V Chemical Disease Relation(CDR).

Cost-effective and efficient sequencing technologies have resulted in massive genomic data availability. To compute on a large-scale genomic dataset, it is often required to outsource the dataset to the cloud. To protect data confidentiality, data owners encrypt sensitive data before outsourcing. Outsourcing enhances data owners to eliminate the storage management problem. Since genome data is large in volume, secure execution of researchers query is challenging. In this paper, we propose a method to securely perform count query on datasets containing genotype, phenotype, and numeric data. Our method modifies the prefix-tree proposed by Hasan et al. [1] to incorporate numerical data. The proposed method guarantees data privacy, output privacy, and query privacy. We preserve the security through encryption and garbled circuits. For a query of 100 single-nucleotide polymorphism (SNPs) sequence, we achieve query execution time approximately 3.5 minutes in a database of 1500 records. To the best of our knowledge, this is the first proposed secure framework that addresses heterogeneous biomedical data including numeric attributes.

As the hottest frontier technology in the field of artificial intelligence, machine learning is subverting various industries step by step. In the future, it will penetrate all aspects of our lives and become an indispensable technology around us. Among them, network security is an area where machine learning can show off its strengths. Among many network security problems, privacy protection is a more difficult problem, so it needs more introduction of new technologies, new methods and new ideas such as machine learning to help solve some problems. The research contents for this include four parts: an overview of machine learning, the significance of machine learning in network security, the application process of machine learning in network security research, and the application of machine learning in privacy protection. It focuses on the issues related to privacy protection and proposes to combine the most advanced matching algorithm in deep learning methods with information theory data protection technology, so as to introduce it into biometric authentication. While ensuring that the loss of matching accuracy is minimal, a high-standard privacy protection algorithm is concluded, which enables businesses, government entities, and end users to more widely accept privacy protection technology.

The bioinformatics features are collected by pattern recognition technology, and the digital coding and format conversion of the feature data are realized by using the theory of topological group transformation. Authentication and Signature based on Zero Knowledge Proof Technology can be used as the trusted credentials of cloud platform and cannot be forged, thus realizing trusted and secure access.

In recent years, there is fast growth in the high throughput DNA sequencing technology, and also there is a reduction in the cost of genome-sequencing, that has led to a advances in the genetic industries. However, the reduction in cost and time required for DNA sequencing there is still an issue of managing such large amount of data. Also, the security and transmission of such huge amount of DNA sequence data is still an issue. The idea is to provide a secure storage platform for future generation bioinformatics systems for both researchers and healthcare user. Secure data sharing strategies, that can permit the healthcare providers along with their secured substances for verifying the accuracy of data, are crucial for ensuring proper medical services. In this paper, it has been surveyed about the applications of blockchain technology for securing healthcare data, where the recorded information is encrypted so that it becomes difficult to penetrate or being removed, as the primary goals of block-chaining technology is to make data immutable.

OLAP is an authoritative analytical tool in the emerging big data analytics context, with particular regards to the target distributed environments (e.g., Clouds). Here, privacy-preserving OLAP-based big data analytics is a critical topic, with several amenities in the context of innovative big data application scenarios like smart cities, social networks, bio-informatics, and so forth. The goal is that of providing privacy preservation during OLAP analysis tasks, with particular emphasis on the privacy of OLAP aggregates. Following this line of research, in this paper we provide a deep contribution on experimenting and assessing a state-of-the-art distributed privacy-preserving OLAP framework, named as SPPOLAP, whose main benefit is that of introducing a completely-novel privacy notion for OLAP data cubes.

Today, intrusion detection and prevention systems (IDS / IPS) are a necessary element of protection against network attacks. The main goal of such systems is to identify an unauthorized access to the network and take appropriate countermeasures: alarming security officers about intrusion, reconfiguration of firewall to block further acts of the attacker, protection against cyberattacks and malware. For traditional computer networks there are a large number of sufficiently effective approaches for protection against malicious activity, however, for the rapidly developing dynamic adhoc networks (Internet of Things - IoT, MANET, WSN, etc.) the task of creating a universal protection means is quite acute. In this paper, we review various methods for detecting polymorphic intrusion activity (polymorphic viral code and sequences of operations), present a comparative analysis, and implement the suggested technology for detecting polymorphic chains of operations using bioinformatics for IoT. The proposed approach has been tested with different lengths of operation sequences and different k-measures, as a result of which the optimal parameters of the proposed method have been determined.

One of the key aspects of IoT-based systems, which we believe has not been getting the attention it deserves, is provenance. Provenance refers to those actions that record the usage of data in the system, along with the rationale for said usage. Historically, most provenance methods in distributed systems have been tightly coupled with those of the underlying data processing frameworks in such systems. However, in this paper, we argue that IoT provenance requires a different treatment, given the heterogeneity and dynamism of IoT-based systems. In particular, provenance in IoT-based systems should be decoupled as far as possible from the underlying data processing substrates in IoT-based systems.To that end, in this paper, we present Genoma, our ongoing work on a system for provenance-as-a-service in IoT-based systems. By "provenance-as-a-service" we mean the following: distributed provenance across IoT devices, edge and cloud; and agnostic of the underlying data processing substrate. Genoma comprises a set of services that act together to provide useful provenance information to users across the system. We also show how we are realizing Genoma via an implementation prototype built on Apache Atlas and Tinkergraph, through which we are investigating several key research issues in distributed IoT provenance.

Networks have evolved very rapidly, which allow secret data transformation speedily through the Internet. However, the security of secret data has posed a serious threat due to openness of these networks. Thus, researchers draw their attention on cryptography field for this reason. Due to the traditional cryptographic techniques which are vulnerable to intruders nowadays. Deoxyribonucleic Acid (DNA) considered as a promising technology for cryptography field due to extraordinary data density and vast parallelism. With the help of the various DNA arithmetic and biological operations are also Blum Blum Shub (BBS) generator, a multi-level of DNA encryption algorithm is proposed here. The algorithm first uses the dynamic key generation to encrypt sensitive information as a first level; second, it uses BBS generator to generate a random DNA sequence; third, the BBS-DNA sequence spliced with a DNA Gen Bank reference to produce a new DNA reference. Then, substitution, permutation, and dynamic key are used to scramble the new DNA reference nucleotides locations. Finally, for further enhanced security, an injective mapping is established to combine encrypted information with encrypted DNA reference using Knight tour movement in Hadamard matrix. The National Institute of Standard and Technology (NIST) tests have been used to test the proposed algorithm. The results of the tests demonstrate that they effectively passed all the randomness tests of NIST which means they can effectively resist attack operations.

Science gateways bring out the possibility of reproducible science as they are integrated into reusable techniques, data and workflow management systems, security mechanisms, and high performance computing (HPC). We introduce BioinfoPortal, a science gateway that integrates a suite of different bioinformatics applications using HPC and data management resources provided by the Brazilian National HPC System (SINAPAD). BioinfoPortal follows the Software as a Service (SaaS) model and the web server is freely available for academic use. The goal of this paper is to describe the science gateway and its usage, addressing challenges of designing a multiuser computational platform for parallel/distributed executions of large-scale bioinformatics applications using the Brazilian HPC resources. We also present a study of performance and scalability of some bioinformatics applications executed in the HPC environments and perform machine learning analyses for predicting features for the HPC allocation/usage that could better perform the bioinformatics applications via BioinfoPortal.

Kerberos is a third party and widely used authentication protocol, in which it enables computers to connect securely using a single sign-on over an insecure channel. It proves the identity of clients and encrypts all the communications between them to ensure data privacy and integrity. Typically, Kerberos composes of three communication phases to establish a secure session between any two clients. The authentication is based on a password-based scheme, in which it is a secret long-term key shared between the client and the Kerberos. Therefore, Kerberos suffers from a password-guessing attack, the main drawback of Kerberos. In this paper, we overcome this limitation by modifying the first initial phase using the virtual password and biometric data. In addition, the proposed protocol provides a strong authentication scenario against multiple types of attacks.

Iris recognition is one of the most reliable biometrics for identification purpose in terms of reliability and accuracy. Hence, in this research the integration of cancelable biometrics features for iris recognition using encryption and decryption non-invertible transformation is proposed. Here, the biometric data is protected via the proposed cancelable biometrics method. The experimental results showed that the recognition rate achieved is 99.9% using Bath-A dataset with a maximum decision criterion of 0.97 along with acceptable processing time.

Malware technology makes it difficult for malware analyst to detect same malware files with different obfuscation technique. In this paper we are trying to tackle that problem by analyzing the sequence of system call from an executable file. Malware files which actually are the same should have almost identical or at least a similar sequence of system calls. In this paper, we are going to create a model for each malware class consists of malwares from different families based on its sequence of system calls. Method/algorithm that's used in this paper is profile hidden markov model which is a very well-known tool in the biological informatics field for comparing DNA and protein sequences. Malware classes that we are going to build are trojan and worm class. Accuracy for these classes are pretty high, it's above 90% with also a high false positive rate around 37%.

Embry-Riddle Aeronautical University (ERAU) is working with the Air Force Research Lab (AFRL) to develop a distributed multi-layer autonomous UAS planning and control technology for gathering intelligence in Anti-Access Area Denial (A2/AD) environments populated by intelligent adaptive adversaries. These resilient autonomous systems are able to navigate through hostile environments while performing Intelligence, Surveillance, and Reconnaissance (ISR) tasks, and minimizing the loss of assets. Our approach incorporates artificial life concepts, with a high-level architecture divided into three biologically inspired layers: cyber-physical, reactive, and deliberative. Each layer has a dynamic level of influence over the behavior of the agent. Algorithms within the layers act on a filtered view of reality, abstracted in the layer immediately below. Each layer takes input from the layer below, provides output to the layer above, and provides direction to the layer below. Fast-reactive control systems in lower layers ensure a stable environment supporting cognitive function on higher layers. The cyber-physical layer represents the central nervous system of the individual, consisting of elements of the vehicle that cannot be changed such as sensors, power plant, and physical configuration. On the reactive layer, the system uses an artificial life paradigm, where each agent interacts with the environment using a set of simple rules regarding wants and needs. Information is communicated explicitly via message passing and implicitly via observation and recognition of behavior. In the deliberative layer, individual agents look outward to the group, deliberating on efficient resource management and cooperation with other agents. Strategies at all layers are developed using machine learning techniques such as Genetic Algorithm (GA) or NN applied to system training that takes place prior to the mission.

The revolution of smart devices has a significant and positive impact on the lives of many people, especially in regard to elements of healthcare. In part, this revolution is attributed to technological advances that enable individuals to wear and use medical devices to monitor their health activities, but remotely. Also, these smart, wearable medical devices assist health care providers in monitoring their patients remotely, thereby enabling physicians to respond quickly in the event of emergencies. An ancillary advantage is that health care costs will be reduced, another benefit that, when paired with prompt medical treatment, indicates significant advances in the contemporary management of health care. However, the competition among manufacturers of these medical devices creates a complexity of small and smart wearable devices such as ECG and EMG. This complexity results in other issues such as patient security, privacy, confidentiality, and identity theft. In this paper, we discuss the design and implementation of a hybrid real-time cryptography algorithm to secure lightweight wearable medical devices. The proposed system is based on an emerging innovative technology between the genomic encryptions and the deterministic chaos method to provide a quick and secure cryptography algorithm for real-time health monitoring that permits for threats to patient confidentiality to be addressed. The proposed algorithm also considers the limitations of memory and size of the wearable health devices. The experimental results and the encryption analysis indicate that the proposed algorithm provides a high level of security for the remote health monitoring system.

Since the first whole-genome sequencing, the biomedical research community has made significant steps towards a more precise, predictive and personalized medicine. Genomic data is nowadays widely considered privacy-sensitive and consequently protected by strict regulations and released only after careful consideration. Various additional types of biomedical data, however, are not shielded by any dedicated legal means and consequently disseminated much less thoughtfully. This in particular holds true for DNA methylation data as one of the most important and well-understood epigenetic element influencing human health. In this paper, we show that, in contrast to the aforementioned belief, releasing one's DNA methylation data causes privacy issues akin to releasing one's actual genome. We show that already a small subset of methylation regions influenced by genomic variants are sufficient to infer parts of someone's genome, and to further map this DNA methylation profile to the corresponding genome. Notably, we show that such re-identification is possible with 97.5% accuracy, relying on a dataset of more than 2500 genomes, and that we can reject all wrongly matched genomes using an appropriate statistical test. We provide means for countering this threat by proposing a novel cryptographic scheme for privately classifying tumors that enables a privacy-respecting medical diagnosis in a common clinical setting. The scheme relies on a combination of random forests and homomorphic encryption, and it is proven secure in the honest-but-curious model. We evaluate this scheme on real DNA methylation data, and show that we can keep the computational overhead to acceptable values for our application scenario.

Genetic data are important dataset utilised in genetic epidemiology to investigate biologically coded information within the human genome. Enormous research has been delved into in recent years in order to fully sequence and understand the genome. Personalised medicine, patient response to treatments and relationships between specific genes and certain characteristics such as phenotypes and diseases, are positive impacts of studying the genome, just to mention a few. The sensitivity, longevity and non-modifiable nature of genetic data make it even more interesting, consequently, the security and privacy for the storage and processing of genomic data beg for attention. A common activity carried out by geneticists is the association analysis between allele-allele, or even a genetic locus and a disease. We demonstrate the use of cryptographic techniques such as homomorphic encryption schemes and multiparty computations, how such analysis can be carried out in a privacy friendly manner. We compute a 3 × 3 contingency table, and then, genome analyses algorithms such as linkage disequilibrium (LD) measures, all on the encrypted domain. Our computation guarantees privacy of the genome data under our security settings, and provides up to 98.4% improvement, compared to an existing solution.

In this paper, we propose a new color image encryption and compression algorithm based on the DNA complementary rule and the Chinese remainder theorem, which combines the DNA complementary rule with quantum chaotic map. We use quantum chaotic map and DNA complementary rule to shuffle the color image and obtain the shuffled image, then Chinese remainder theorem from number theory is utilized to diffuse and compress the shuffled image simultaneously. The security analysis and experiment results show that the proposed encryption algorithm has large key space and good encryption result, it also can resist against common attacks.

Free-text keystroke authentication has been demonstrated to be a promising behavioral biometric. But unlike physiological traits such as fingerprints, in free-text keystroke authentication, there is no natural way to identify what makes a sample. It remains an open problem as to how much keystroke data are necessary for achieving acceptable authentication performance. Using public datasets and two existing algorithms, we conduct two experiments to investigate the effect of the reference profile size and test sample size on False Alarm Rate (FAR) and Imposter Pass Rate (IPR). We find that (1) larger reference profiles will drive down both IPR and FAR values, provided that the test samples are large enough, and (2) larger test samples have no obvious effect on IPR, regardless of the reference profile size. We discuss the practical implication of our findings.

Session management in distributed Internet services is traditionally based on username and password, explicit logouts and mechanisms of user session expiration using classic timeouts. Emerging biometric solutions allow substituting username and password with biometric data during session establishment, but in such an approach still a single verification is deemed sufficient, and the identity of a user is considered immutable during the entire session. Additionally, the length of the session timeout may impact on the usability of the service and consequent client satisfaction. This paper explores promising alternatives offered by applying biometrics in the management of sessions. A secure protocol is defined for perpetual authentication through continuous user verification. The protocol determines adaptive timeouts based on the quality, frequency and type of biometric data transparently acquired from the user. The functional behavior of the protocol is illustrated through Matlab simulations, while model-based quantitative analysis is carried out to assess the ability of the protocol to contrast security attacks exercised by different kinds of attackers. Finally, the current prototype for PCs and Android smartphones is discussed.