Hardware security, whether for attack or defense, differs from software, network, and data security in that attackers may find ways to physically tamper with devices without leaving a trace, and mislead the user to believe that the hardware is authentic and trustworthy. Furthermore, the advent of new attack modes, illegal recycling, and hard-to-detect Trojans make hardware protection an increasingly challenging task. Design of secure hardware integrated circuits requires novel approaches for authentication that are ideally based on multiple layers of protection.